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Science 274, 13791383

The body's natural production of CoQ10 appears to decline with age, and certain medications, particularly statins, can reduce endogenous levels

Goya K, Sumitani S, Otsuki M, Xu X, Yamamoto H, Kurebayashi S, Saito H, Kouhara H, Kasayama S (2006) The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells